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The 1st Coronavirus Vaccine ‘mRNA-1273’ Ready for Human Experimental Test

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The 1st Coronavirus Vaccine has been discovered for experimental testing in United states of America.

The new vaccine is a collaboration between NIAID scientists and the biotechnology company Moderna Inc., based in Cambridge, Massachusetts.

Covid-19 which is the disease caused by Coronavirus has been a threat to human lives and National Economy systems. However, it seems that we are getting close to eliminating this deadly virus.

The vaccine was fast-tracked to human trials, but more time is needed before it’s ready for public use. A healthy volunteer in Seattle is the first person in the U.S.A. to receive a dose of an experimental coronavirus vaccine as part of a new clinical trial announced by the government health officials on March 16th.

Also Read: Coronavirus: Safety Health Measures Beyond the Surgical Mask and Hand Sanitizers

The National Institute of Allergy and Infectious Diseases (NIAID) allowed the new vaccine to be fast-tracked into clinical trials without thorough testing in animal models, which usually stands as a strict prerequisite to human testing. While making the jump to human trials could bring the vaccine to market faster, this is only step one.

In the next 6 weeks, researchers plan to enroll 45 participants in the trial, which will test the safety of the vaccine as well as its ability to induce an immune response in the volunteers. The trial will be taking place at Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle.

However, NIAID Director Dr. Anthony Fauci told the House Oversight and Reform Committee that this new Vaccine must pass through 3 iterative phases of clinical trials before being deemed safe and effective for widespread use. Assuming the initial tests go well, it may take 12 to 18 months before any vaccine is ready for public use.  

“Finding a safe and effective vaccine to prevent infection with SARS-CoV-2 is an urgent public health priority,” Fauci said in a NIAID statement, published March 16. “This Phase 1 study, launched in record speed, is an important first step toward achieving that goal.”

PHASE 1 TRIAL:

According to the U.S. Food and Drug Administration (FDA), this trial launched today is known as a “Phase 1 clinical trial,” meaning its main purpose is to provide information about how the vaccine interacts with a healthy human body.

Phase 1 trials examine a small group of people, typically between 20 and 80 individuals, who received different doses of an experimental treatment. Over the course of several months, researchers monitor how each volunteer metabolizes the given treatment and what common side effects emerge in response to different doses.

The 45 volunteers in the new trial will receive varying doses of the new vaccine called ‘mRNA-1273’ and they will be monitored over a 14-month period.

Volunteers will receive two injections of the vaccine in the upper arm, with a 28-day gap between doses. The first participant will receive the lowest dose of the vaccine, at 25 micrograms (mcg) per injection, according to the NIAID statement.

Three others will receive the same initial dose, and four more will each receive a 100-mcg dose of the vaccine and be thoroughly evaluated before any volunteers are given their second dose.

According to ClinicalTrials.gov., if participants’ reactions to the low doses prove acceptable, a third group of participants will receive 250 mcg of the vaccine per injection. In addition to monitoring for side effects, the researchers will test whether the vaccine triggers an immune response by analyzing the volunteers’ blood for antibodies.

However, If the vaccine works as designed, the immune system should generate antibodies that grab hold of a characteristic protein found on the surface of the novel coronavirus SARS-CoV-2.

Kaiser Permanente, the health care company conducting the trial said instead of introducing a dead or weakened virus into the body to prompt this reaction, as conventional vaccines do, the vaccine instructs cells to build the viral protein themselves using a molecule called messenger RNA (mRNA). Once utilized by the body, the mRNA should break down and be eliminated, leaving only protective antibodies behind. 

PHASE 2 TRIAL:

According to the U.S. Centers for Disease Control and Prevention (CDC), the drug must then be tested in larger groups of people and over longer periods of time, in Phase 2 and Phase 3 trials.

Phase 2 trials typically examine several hundred people and monitor participants for periods of from several months to two years.

Worthy of note, Phase 2 trials serve as a secondary measure of safety and help researchers to refine the dosing of a particular medication. At this stage, researchers select participants with characteristics, such as age and physical health, that match those of the people who the vaccine is being developed for. (For example, although anyone can contract COVID-19, those of advanced age and those with chronic conditions are more likely to develop severe symptoms, so this could be a consideration in Phase 2 trials.)

PHASE 3 TRIAL:

According to the FDA, Phase 3 trials typically follows 300 to 3,000 volunteers over the course of one to four years; with a larger group of people, researchers can take note of unusual side effects of the drug, and by lengthening the study period, they can catch long-term side effects as they emerge.

Phase 3 trials must demonstrate that a given drug provides the medical benefits it’s intended to; if this coronavirus vaccine passes that test, the FDA could approve the drug for widespread use.

PHASE 4 TRIAL:

Following approval by the FDA, drugs undergo Phase 4 clinical trials, otherwise known as “post-marketing surveillance trials.” Once a drug enters public use, researchers monitor several thousand volunteers to spot side effects not seen in earlier trials and to track how well the vaccine works over extended periods of time, according to the National Cancer Institute.

Although this coronavirus vaccine may or may not reach Phase 4 trials in the coming years, limited studies have shown promising results. In the meantime, research groups around the world will continue to develop alternate vaccines to combat the spread of COVID-19.

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2023 Presidency: Youth Support Group gives Governor Yahaya Bello 14 days ultimatum to join presidential race or risk nationwide protest 

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2023 Presidency: Youth Support Group Gives Yahaya Bello 14 days Ultimatum to declear interest..

The coalition of youth support groups, under the name of “Governor Yahaya Bello to President Yahaya Bello’’ (GYB2PYB), has issued 14 days ultimatum to Governor Bello to declare intentions’ joining the 2023 presidential race or risk a nationwide protest

The group made their position known in a letter of invitation to contest 2023 presidential race submitted to Governor Bello at the Kogi State liaison office in Abuja on Friday

Ambassador Oladele Nihi Director General GYB2PYB said that Governor Bello has what it takes to provide purposeful leadership and good governance if elected as President in the 2023 General Elections.

“He will offer the right leadership, as he is interested in the good of Nigeria. The GYB2PYB Youth Movement is not a selfish Agenda, but an effort to project him, to market him, and to sell him to other Nigerians.

“We have searched the length and breadth of our country and found that Governor Yahaya Bello, a young man who has given women and young people the platform to be the drivers in their own affairs, will perform well if elected into the exalted office.

“The GYB (Gov. Yahaya Bello), style of leadership is what we need in this country, the leadership of a government of the young people by the young people and for the general wellbeing of all Nigerians.

“Over fifteen million Nigerian young men and women have signed a request letter to His Excellency, Governor Yahaya Bello, calling on him to accept to contest the position of the President and Commander in Chief of the Armed Forces of the Federal Republic of Nigeria in 2023.

“We believe Governor Yahaya Bello to be a detribalized Nigerian. He will stamp out Nepotism from our country, and he will handle the intractable security problems of our country.

“Because he is a young man, he will engage the women and the young men in governance and make them critical stakeholders in the affairs of the country. We believe that he is a good brand that we can sell.

We urge Nigerian youths to take the message nationwide, that Governor Yahaya Bello will handle security; he will ensure Women and Youth Inclusiveness in governance, erase all forms of ethnic and religious bias and bring massive Foreign Direct Investments into the Country.

Right now, we need a leader that can hold our country together. We are saying that the person is Governor Yahaya Bello. I believe that the challenge is to have a good leader to succeed President Muhammadu Buhari, who has tried his best. We should begin to identify somebody to take over from him and do a fantastic job.

We will make it impossible for GYB to say NO, because he holds it to Nigerians to participate in the election. It is a patriotic duty we are calling on him for. He is a man who believes in the progress and development of Nigeria, he has no choice than to accede to our request. He should come out and offer himself for the leadership of this country at this time. We are calling on him to serve. We are confident that he will come out and run for the presidency.

Recall that the group had sometime last year predicted that 2023 would be a youth political revolution year in Nigeria, saying it planned to build early structures among youth groups, to network towards possible and inevitable takeover of leadership.

Also Read;

The GYB2PYB, expressed regrets that Nigeria, with a population of more than 200 million people, 75 per cent of which were youth, said it was disheartening that less than one per cent of young Nigerians are currently included, appointed or elected into leadership positions in the country.

It said the group was set to change the narrative come 2023

“We decided to search for three qualities; a young person with capacity politically and financially, one who is already in the political system/power block and who has the track record of youth engagement and inclusion in governance, as well as appointments, requirements we found in Governor Bello,’’ it said in a statement.

Hon. Bar Medina Anako, Special adviser intergovernmental affairs and State focal person, Nigerians in diaspora Commission received the group on behalf of the Governor

Barrister Anako has assured the group that Governor Bello will surely respond to their letter of invitation asking him to join the race within the next 14 days as demanded!!

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THE MESSAGE OF THE HON. SPEAKER OF NDIGBO YOUTH PARLIAMENT (NYP), RT. HON. RIKKI CHINEDU NWAJIOFOR, ON ARMED FORCES REMEMBRANCE DAY.

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NDIGBO YOUTH PARLIAMENT

Armed Forces Remembrance Day; The Heroes of Our Land!
“The soldier above all others prays for peace, for it is the soldier who must suffer and bear the deepest wounds and scars of war.”
—Douglas MacArthur.

“Only a life lived for others is a life worthwhile”, opines Albert Einstein. Suffice it to say that the spirit cum the zeal to serve selflessly and pour out oneself profusely in service, for the good of “a neighbor” and betterment of the nation at large, is a worthwhile life. Such a life depicts a Patriot and a Nationalist.

Today, the 15th day of January has been dedicated as a day we remember and pay homage to the selfless and unquantifiable sacrifices our armed forces made and still make for us as individuals and for the nation at large. Today is a day to honour all those brave Men and Women who have served or are still serving their country with bravery, dedication and self-sacrifice.

Yes, they put up selfless sacrifices for us; keeping awake that we might sleep and giving their lives that we might not lose all the things we love. As we sleep peacefully on our beds, our “Gallant Men and Valiant Women” stand on guard, ready to give their lives for our freedom. They keep awake in the bush, in cold weather, on high sea, to make sure we sleep and snore peacefully. They are separated from their families and loved ones so we can be united with ours. They lay down their lives that we might live.

As a country, they give up themselves that we can be united and have our sovereignty upheld. According to Barrack Obama, “the soldier’s courage and sacrifice is full of glory, expressing devotion to country, to cause, to comrades in arms.” In all these their invaluable sacrifices, we need to appreciate them. We need to let them know that we are grateful. Buttressing this further, Harry S. Truman asserts; “our debt to the Heroic men and Valliant women in the service of our country can never be repaid. They have earned our undying gratitude. We will never forget their sacrifices.”

Yes, we should never forget their unflinching and unwavering loyalty and love for our beloved nation; we should never forget their unquantifiable sacrifices.

An epitaph on a soldier’s grave reads:
I did my duty,
I paid the supreme price,
I pray you’ll remember,
My sacrifice.
My life was short,
I did my best.
God grant me peace,
In my eternal rest.

What a heart-rending epitaph! Yes, they wish that we forget not their sacrifices. “The labours and sacrifices of our Heroes past shall never be in vain”! Let us remember to extend helping hands to their widows, widowers, bereaved siblings and orphaned children. They are in that condition today because their loved ones laid down their lives that we might enjoy the company of our own loved ones.

May God strengthen and bless all our military men, comfort the families of those who lost their lives for our sake and grant blissful rest to our departed Heroes. We are proud of you!!!

“A true Soldier fights not because he hates what is in front of him, but because he loves what is behind him”.
G.K. Chesterton.

By: Rt. Hon. Rikki Chinedu Nwajiofor.
Speaker, Ndigbo Youth Parliament (NYP).

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Police recovers the genital organ of 6-year-old girl mutilated by ritualists in Bauchi

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Police recovers the genital organ of 6-year-old girl mutilated by ritualists in Bauchi

The Bauchi Police Command has recovered a genital organ suspected to belong to the 6-year-old girl mutilated by ritualists in Jamaare Local Government Area of the state.

Police recover genital organ of 6-year-old girl mutilated by ritualists in Bauchi

Recall that two suspects Abdulkadir Wada Haladu, 19, and Adamu Abdulrauf, 20, were arrested in connection with the crime. Wada was nabbed in Mararraba, Nasarawa State where he voluntarily confessed to the crime.

Spokesperson of the command, Wakil, who confirmed the development in a statement on Wednesday, January 13, said a bottle containing the suspected genital organ (complete Vulva; Libia Majora, Libia Minora and clitoris) was recovered in the house of one of the suspected ritualists, Abdulkadir Wada Haladu.

Police recover genital organ of 6-year-old girl mutilated by ritualists in Bauchi

Other items recovered include two knives, three bottles containing native medicine.
One carton containing some native dry medicines tied inside polythene bags, one dry animal skin, two Islamic native black boards, one calabash, one hoe, and two locally made Disks.

Police recover genital organ of 6-year-old girl mutilated by ritualists in Bauchi

 

 

 

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