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The 1st Coronavirus Vaccine ‘mRNA-1273’ Ready for Human Experimental Test

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The 1st Coronavirus Vaccine has been discovered for experimental testing in United states of America.

The new vaccine is a collaboration between NIAID scientists and the biotechnology company Moderna Inc., based in Cambridge, Massachusetts.

Covid-19 which is the disease caused by Coronavirus has been a threat to human lives and National Economy systems. However, it seems that we are getting close to eliminating this deadly virus.

The vaccine was fast-tracked to human trials, but more time is needed before it’s ready for public use. A healthy volunteer in Seattle is the first person in the U.S.A. to receive a dose of an experimental coronavirus vaccine as part of a new clinical trial announced by the government health officials on March 16th.

Also Read: Coronavirus: Safety Health Measures Beyond the Surgical Mask and Hand Sanitizers

The National Institute of Allergy and Infectious Diseases (NIAID) allowed the new vaccine to be fast-tracked into clinical trials without thorough testing in animal models, which usually stands as a strict prerequisite to human testing. While making the jump to human trials could bring the vaccine to market faster, this is only step one.

In the next 6 weeks, researchers plan to enroll 45 participants in the trial, which will test the safety of the vaccine as well as its ability to induce an immune response in the volunteers. The trial will be taking place at Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle.

However, NIAID Director Dr. Anthony Fauci told the House Oversight and Reform Committee that this new Vaccine must pass through 3 iterative phases of clinical trials before being deemed safe and effective for widespread use. Assuming the initial tests go well, it may take 12 to 18 months before any vaccine is ready for public use.  

“Finding a safe and effective vaccine to prevent infection with SARS-CoV-2 is an urgent public health priority,” Fauci said in a NIAID statement, published March 16. “This Phase 1 study, launched in record speed, is an important first step toward achieving that goal.”

PHASE 1 TRIAL:

According to the U.S. Food and Drug Administration (FDA), this trial launched today is known as a “Phase 1 clinical trial,” meaning its main purpose is to provide information about how the vaccine interacts with a healthy human body.

Phase 1 trials examine a small group of people, typically between 20 and 80 individuals, who received different doses of an experimental treatment. Over the course of several months, researchers monitor how each volunteer metabolizes the given treatment and what common side effects emerge in response to different doses.

The 45 volunteers in the new trial will receive varying doses of the new vaccine called ‘mRNA-1273’ and they will be monitored over a 14-month period.

Volunteers will receive two injections of the vaccine in the upper arm, with a 28-day gap between doses. The first participant will receive the lowest dose of the vaccine, at 25 micrograms (mcg) per injection, according to the NIAID statement.

Three others will receive the same initial dose, and four more will each receive a 100-mcg dose of the vaccine and be thoroughly evaluated before any volunteers are given their second dose.

According to ClinicalTrials.gov., if participants’ reactions to the low doses prove acceptable, a third group of participants will receive 250 mcg of the vaccine per injection. In addition to monitoring for side effects, the researchers will test whether the vaccine triggers an immune response by analyzing the volunteers’ blood for antibodies.

However, If the vaccine works as designed, the immune system should generate antibodies that grab hold of a characteristic protein found on the surface of the novel coronavirus SARS-CoV-2.

Kaiser Permanente, the health care company conducting the trial said instead of introducing a dead or weakened virus into the body to prompt this reaction, as conventional vaccines do, the vaccine instructs cells to build the viral protein themselves using a molecule called messenger RNA (mRNA). Once utilized by the body, the mRNA should break down and be eliminated, leaving only protective antibodies behind. 

PHASE 2 TRIAL:

According to the U.S. Centers for Disease Control and Prevention (CDC), the drug must then be tested in larger groups of people and over longer periods of time, in Phase 2 and Phase 3 trials.

Phase 2 trials typically examine several hundred people and monitor participants for periods of from several months to two years.

Worthy of note, Phase 2 trials serve as a secondary measure of safety and help researchers to refine the dosing of a particular medication. At this stage, researchers select participants with characteristics, such as age and physical health, that match those of the people who the vaccine is being developed for. (For example, although anyone can contract COVID-19, those of advanced age and those with chronic conditions are more likely to develop severe symptoms, so this could be a consideration in Phase 2 trials.)

PHASE 3 TRIAL:

According to the FDA, Phase 3 trials typically follows 300 to 3,000 volunteers over the course of one to four years; with a larger group of people, researchers can take note of unusual side effects of the drug, and by lengthening the study period, they can catch long-term side effects as they emerge.

Phase 3 trials must demonstrate that a given drug provides the medical benefits it’s intended to; if this coronavirus vaccine passes that test, the FDA could approve the drug for widespread use.

PHASE 4 TRIAL:

Following approval by the FDA, drugs undergo Phase 4 clinical trials, otherwise known as “post-marketing surveillance trials.” Once a drug enters public use, researchers monitor several thousand volunteers to spot side effects not seen in earlier trials and to track how well the vaccine works over extended periods of time, according to the National Cancer Institute.

Although this coronavirus vaccine may or may not reach Phase 4 trials in the coming years, limited studies have shown promising results. In the meantime, research groups around the world will continue to develop alternate vaccines to combat the spread of COVID-19.

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PRESIDENT BUHARI RECEIVES THE LETTER OF GRATITUDE FROM THE PRESIDENT OF NYCN – AMB. SUKUBO SARA-IGBE SUKUBO, CHARGES SUKUBO TO SET UP SUPPORT CENTERS ACROSS NIGERIA.

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PRESIDENT BUHARI RECEIVES THE LETTER OF GRATITUDE FROM THE PRESIDENT OF NYCN – AMB. SUKUBO SARA-IGBE SUKUBO, CHARGES SUKUBO TO SET UP SUPPORT CENTERS ACROSS NIGERIA.

“The heights the great men reached and kept were not attained by sudden flight, but they while their companions slept, were toiling upward in the night”, opines Henry Wadsworth Longfellow.

WhatsApp Image 2020-08-06 at 5.00.24 PM

Today, history has again been made in the Youth Constituency as the President of the National Youth Council of Nigeria – Amb. Sukubo Sara-Igbe Sukubo, in the company of some past Presidents and NEC members of the National Youth Council of Nigeria, held a closed door meeting with the Honorable Minister of Youth and Sports Development, Hon. Sunday Dare, at the Ministry of Youth and Sports Development. Present at the meeting include the Permanent Secretary, Mr. Gabriel Tanimu Aduda, the Director Press and other Directors of the Ministry of Youth and Sports Development.

WhatsApp Image 2020-08-06 at 5.00.23 PMThe President of NYCN, Amb. Sukubo Sara-Igbe Sukubo, in his speech eulogized the Honorable Minister as a digital and innovative Minister who works round the clock to better the development of the entire Nigerian Youth.

Amb. Oladele John Nihi, the Hon. Commissioner of PYU and Past President of NYCN, thanked the Hon. Minister for his innovative prowess and urged him to keep on making giant strides in the Youth development. He also reiterated the need for the ministry to be the galvanizing point of all the Youth programmes and projects that are scattered in all other ministries, as the mother ministry of the Nigerian Youth.

In his Speech, the Honorable Minister, who just came back from the Presidential Villa after handing over the letter from Amb. Sukubo to President Buhari, conveyed the salutations of President Buhari to Amb. Sukubo.

WhatsApp Image 2020-08-06 at 5.00.22 PMThe Minister appreciated the gratitude gesture from the entire Nigerian Youth, through the National Youth Council of Nigeria, to him and to President Buhari for the establishment of the Nigeria Youth Investment Fund (NYIF). He reiterated the commitment of this administration in championing the development and welfare of the Youth of Nigeria.

“This administration, through the Ministry of Youth and Sports Development, will do everything possible to keep Nigeria Youth meaningfully and gainfully busy. The overall development and upliftment of the Nigerian Youth is our priority. In fact, in the next ten to fifteen years, Nigeria will no longer pride in her oil but in the proficiency, efficiency and innovations of her creative Youth.

The Hon. Minister used the opportunity to break another good news to the Youth Constituency of Nigeria. According to him, aside the Nigeria Youth Investment Fund (NYIF), another mindblowing and stunning initiative for the development of the Nigerian Youth will be deliberated upon by next week. In his words, “it is something that will gladden the hearts of the entirety of the Nigerian Youth and put them in the front agenda of this country.”

In the light of the forthcoming projects, the Honorable Minister charged the President of National Youth Council of Nigeria, Amb. Sukubo Sara-Igbe Sukubo, to set up support centers across the country. The Support Centers will serve as “a go-between” for the Ministry of Youth and Sports Development and the Nigeria Youth at the grassroots. The support centers will be the centers of inquiry for the Nigerian Youth, regarding the various projects that will be rolled out by the Ministry.

Toeing the good thread of National Youth Council of Nigeria (NYCN), the Speaker of the Nigerian Youth Parliament (NYP), accompanied by some of his Excos, extended gratitude gesture to the Hon. Minister and President Buhari, in appreciation for the Nigeria Youth Investment Fund (NYIF). At the end of the visit, the Hon. Minister had a photo section with NYCN and NYP.

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FIGHR TO TRAIN VOLUNTEERS ON GENDER BASED VIOLENCE

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FIGHR TO TRAIN VOLUNTEERS ON GENDER BASED VIOLENCE
FIGHR TO TRAIN VOLUNTEERS ON GENDER BASED VIOLENCE

By Millicent Umoru-O

The Federation of International Gender and Human Right (FIGHR) a Division of the Maternal Care Project of United Nations (UN) Women Gambia, New York held its 2020 cohort Fellowship on Gender Based and Human Rights Violence (GBV) Advocacy program.

Gistflash gathered that the fellowship which is the first of its kind will be a joint venture, focusing on the development of the Global Ambassador Program as offered by Global Minds Connect (GMC) and Peer Advocacy Education Program as offered within FIGHR. This cohort offers to assist GMC and their pledge to educate and embark on ‘‘One Million Ambassadors’’ to help eradicate GBV and governing bodies of the African Union, ECOWAS and the United Nations in their effort of ending Gender Based Violence, internationally.

The Founder and Lead Advocate, FIGHR, Dr Ameena Ali, during the FIGHR 2020 Gender Based Violence Advocacy Fellowship organized to raise Global Youth Ambassadors said the mission of the fellowership, amongst others is to make sure there is a voice for all those affected by Gender based violence. Adding that the vision is to be a solution to GBV and empower the younger generations with education and knowledge in eradicating GBV.

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Dr. Ameena said the inaugural meeting is to introduce the participants and also give an insight on what the 12 weeks training will entail.

adding that, the training will all be done virtually and after the training, participants will be certified as well as become Ambassadors for Gender Based Violence in their countries.

The virtual meeting featured participants from different countries, including Nigeria, Ghana, India, South Sudan, Afganistan etc.

She urged all to take the 12 weeks training seriously so as to be able to teach and advocate for the eradication of Gender Based Violence in their various countries. She noted that, a certificate will be issued at the end of the training

According to Dr. Ameena, after the 12 weeks training, Ambassadors will be required to go out and teach, enlighten as well as help people in both urban and rural areas to know more about Gender Based Violence and assist in eradicating it.

She further stated that the certificate will facilitate the registration of Non Governmental organisation (NGOs) and Community Service Organisations (CSOs), as that will help the ambassadors reach out to the needed audience. The training which started on 4th of August, 2020 will run till October 2020.

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Fire Razes Popular Market in Ajman, United Arab Emirates (Video)

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united arab emirates
Fire Razes Popular Market in Ajman, United Arab Emirates (Video)

A large fire broke out on Wednesday evening at a market in the emirate of Ajman in the United Arab Emirates, according to local media reports and a source present at the scene.

The witness told Reuters the fire, which was earlier reported by The National and Gulf News newspapers, was being tackled by emergency services.

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Local officials could not immediately be reached for comment or confirmation, and no statements were carried by state media.

This comes few hours after the Beirut fire outbreak that claimed over a hundred lives.

As at the time of filing this report, the cause of the fire outbreak isn’t known yet.

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